| Bisphosphonates |
- Reduces risk of
clinical fragility fractures Fragility fractures are bone breaks from a normal activity, or from a minor incident or fall that would not cause a bone to break in a healthy adult. Most common types of these breaks are hip and spine fractures. (Moderate certainty evidence)
- Reduces risk of
hip fractures A hip fracture is when a hip bone breaks from normal daily activity, or from a minor incident that would not cause a bone to break in a healthy adult
(Low certainty evidence)
- Reduce risk of
clinical vertebral fractures
A clinical vertebral fracture is when a spine bone breaks from normal daily activity, or from a minor incident that would not cause a bone to break in a healthy adult. (Low certainty evidence)
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- Generally, there is a very low to no likelihood of any serious side effects and very few discontinued their medication due to side-effects (Low certainty evidence)
- May include increased risk of
atypical femoral fractures
Atypical femoral fracture is a rare side effect which causes the thigh bone to break or osteonecrosis of the jaw Osteonecrosis of jaw is a rare condition causing the deterioration of the jawbone (<1-2 per 10,000)
(Low certainty evidence)
- Low likelihood (1-6%) of non-serious side effects, such as abdominal issues (e.g., reflux) or flu-like symptoms (Low to moderate certainty evidence)
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